发明名称 |
COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 |
摘要 |
The present invention relates to compounds of formula I: in which Y, Y1, Y 4, Y5, Y 6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers. |
申请公布号 |
CA2870339(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
CA20132870339 |
申请日期 |
2013.05.09 |
申请人 |
NOVARTIS AG |
发明人 |
FURET, PASCAL;GROTZFELD, ROBERT MARTIN;JONES, DARRYL BRYNLEY;MANLEY, PAUL;MARZINZIK, ANDREAS;MOUSSAOUI, SALIHA;PELLE, XAVIER FRANCOIS ANDRE;SALEM, BAHAA;SCHOEPFER, JOSEPH;JAHNKE, WOLFGANG |
分类号 |
C07D213/81;A61K31/505;C07D213/85;C07D231/12;C07D233/38;C07D233/54;C07D239/26;C07D239/30;C07D239/34;C07D241/12;C07D241/20;C07D277/20;C07D317/60;C07D401/04;C07D407/14 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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