发明名称 |
Synthesis of decitabine |
摘要 |
A method for producing a beta-enriched protected decitabine comprising: a) coupling a protected 2-deoxy-ribofuranose with a protected 5-azacytosine in the presence of a catalyst to form a reaction mixture comprising the protected decitabine of formula I; and b) quenching the reaction mixture of step a) with a base. The beta-enriched protected decitabine so made may be deprotected to produce a decitabine product in a high yield and purity.
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申请公布号 |
US8586729(B2) |
申请公布日期 |
2013.11.19 |
申请号 |
US20090572578 |
申请日期 |
2009.10.02 |
申请人 |
HENSCHKE JULIAN PAUL;ZHANG XIAOHENG;YU JIANBO;HU KUN;MEI LIJUN;SCINOPHARM TAIWAN LTD. |
发明人 |
HENSCHKE JULIAN PAUL;ZHANG XIAOHENG;YU JIANBO;HU KUN;MEI LIJUN |
分类号 |
C08B37/00;C07H5/04;C07H5/06 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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