摘要 |
The invention relates to compounds derived from 4-arylmethylene-1,3-azol-5-one, with or without amino substitutes in the R1 position, with activity as calpain inhibitors. Said compounds have the general formula (I), where R1, R2, X, Y and W have the meaning mentioned in the description and in the claims, the tautomers and the possible salts thereof. In particular, said compounds have the general formulae (l-A.), (I-B.) y (l-C), where R1, R2, R3, R4, R5 X, Y and Z have the meaning mentioned in the description and the claims, the tautomers and the possible salts thereof. Compounds (I) can be used in preventive or therapeutic treatment of disorders related to elevated levels of calpain activity.
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申请人 |
UNIVERSIDAD DE ALCALA |
发明人 |
MORON GALAN, MARIA;BURGOS GARCIA, CAROLINA;VAQUERO LOPEZ, JUAN JOSE;GRIERA MERINO, MERCEDES;DIEZ MARQUES, MARIA LUISA;RODRIGUEZ PUYOL, MANUEL;RODRIGUEZ PUYOL, DIEGO |