发明名称 |
CONFORMATIONALLY SPECIFIC VIRAL IMMUNOGENS |
摘要 |
The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine. |
申请公布号 |
WO2013169961(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2013US40228 |
申请日期 |
2013.05.09 |
申请人 |
MARSHALL, CHRISTOPHER, PATRICK |
发明人 |
MARSHALL, CHRISTOPHER, PATRICK |
分类号 |
A61K39/12;A61K39/42;C12N7/01 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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