| 发明名称 |
Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use |
| 摘要 |
Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
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| 申请公布号 |
US8580850(B2) |
申请公布日期 |
2013.11.12 |
| 申请号 |
US201213572367 |
申请日期 |
2012.08.10 |
| 申请人 |
RAILLARD STEPHEN P.;MANTHATI SURESH K.;JOSHI SUDHIR;XENOPORT, INC. |
发明人 |
RAILLARD STEPHEN P.;MANTHATI SURESH K.;JOSHI SUDHIR |
| 分类号 |
C07C271/22;A61K31/27;A61P1/04;A61P11/00;A61P19/00;A61P25/30;A61P29/00;C07C269/08 |
主分类号 |
C07C271/22 |
| 代理机构 |
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