发明名称 |
POLYMORPHIC FORMS OF 6-(1-METHYL-1H-PYRAZOL-4-YL)-2-{3-[5-(2-MORPHOLIN-4-YL-ETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-2H-PYRIDAZIN-3-ONE DIHYDROGENPHOSPHATE AND PROCESSES OF MANUFACTURING THEREOF |
摘要 |
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer. |
申请公布号 |
UA103646(C2) |
申请公布日期 |
2013.11.11 |
申请号 |
UA20110009101 |
申请日期 |
2009.11.24 |
申请人 |
MERCK PATENT GMBH |
发明人 |
BECKER, AXEL;KUEHN, CLEMENS;SAAL, CHRISTOPH;SCHADT, OLIVER;DORSCH, DIETER;KRIEGBAUM, EVA;STIEBER, FRANK;DONINI, CHRISTINA |
分类号 |
C07D403/14;A61K31/506;A61P35/02 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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