Gene Delivery Complex Comprising Renal Cell-Specific Peptide and Polyester Amine and Composition Comprising The Same for Preventing or Treating of Renal Fibrosis.

摘要

PURPOSE: A gene delivery system containing renal cell-specific peptides and polyester amine polymers is provided to effectively deliver HGF gene to a target site and to suppress fibrosis. CONSTITUTION: A gene delivery system contains renal cell-specific peptides and polyester amine polymers. The renal cell-specific peptide is HOOC-ELRGDRAHW-NH_2. The polyester amine polymer is a copolymer of polyethylenimine and glycerol dimethacrylate. The delivery system is prepared by amide bond of a carboxyl group of rental cell-specific peptides and an amine group of polyester amine polymers. A HGF gene contains a base of sequence number 1. A composition for preventing or treating rental fibrosis contains a gene delivery complex.