发明名称 |
2-O SULFATASE COMPOSITIONS AND RELATED METHODS |
摘要 |
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase. |
申请公布号 |
CA2512673(C) |
申请公布日期 |
2013.11.05 |
申请号 |
CA20042512673 |
申请日期 |
2004.01.07 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
SASISEKHARAN, RAM;MYETTE, JAMES R.;SHRIVER, ZACHARY;VENKATARAMAN, GANESH |
分类号 |
C12N9/16;C12N15/09;A61K;A61K38/46;A61P9/10;A61P25/28;A61P31/00;A61P35/00;A61P43/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12Q1/44;C12Q1/68 |
主分类号 |
C12N9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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