发明名称 |
Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
摘要 |
Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25- hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample. |
申请公布号 |
AU2012259080(A1) |
申请公布日期 |
2013.10.31 |
申请号 |
AU20120259080 |
申请日期 |
2012.05.18 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS, INC.;CAMPBELL, BRUCE;LIN, SPENCER;LIAO, QIMU |
发明人 |
SAHAKIAN, NIVER PANOSIAN;CAMPBELL, BRUCE A.;LIN, SPENCER HSIANG-HSI;FREEMAN, JAMES VINCENT;LIAO, QIMU;EVANGELISTA, RAMON A. |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|