发明名称 |
Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof |
摘要 |
The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
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申请公布号 |
US2013287699(A1) |
申请公布日期 |
2013.10.31 |
申请号 |
US201313742190 |
申请日期 |
2013.01.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHANG CHRISTOPHER J.;BERTOZZI CAROLYN R.;VAN DE BITTNER GENEVIEVE C.;DUBIKOVSKAYA ELENA A. |
分类号 |
A61K49/00 |
主分类号 |
A61K49/00 |
代理机构 |
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地址 |
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