4-((SUBSTITUTED PHENYL) DIFLUOROMETHYL) PHENOXY CARBOXYLIC ACID DERIVATIVE, AND PREPARATION METHOD AND USES THEREOF

摘要

Disclosed are a 4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid derivative, and preparation method and uses thereof. More particularly, the present invention relates to a compound having a structure as represented by formula I and defined in the description. The compound of the present invention can be used as a PPAR agonist, and demonstrates a relatively strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in plasma. Therefore, the compound of the present invention can be used to prepare drugs for treating or preventing hyperlipemia, or cardiovascular and cerebrovascular diseases caused by hyperlipemia, such as diabetes, atherosclerosis, stroke, and coronary heart disease. The present invention also relates to a novel intermediate compound for preparing the compound as represented by formula I, and preparation method thereof.