SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES

摘要

600716 Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables are defined in the specification, a pharmaceutical composition comprising said compound, and the use of said compound in the treatment of a disease or disorder mediated by the activity of MDM2 and/or MDM4 such as cancer. Embodiments of the compound include the following: (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-2-( 4-{ methyl-[4-(3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino} phenyl)-1,4-dihydro-2H-isoquinolin-3-one, and 4-[(S)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-N-ethyl-N-methyl-benzamide.