发明名称 |
MicroRNA target site for cell- or tissue-specific inhibition of expression of a transgene |
摘要 |
The present invention is directed to an isolated miR-206 target site, comprising or consisting of a nucleic acid sequence with a sequence identity of at least 80% compared to wild type miR-206 target site with SEQ ID No. 1, characterized in that the nucleic acid sequence comprises at least one nucleotide substitution at a position from nucleotide 2 to 8 and/or at least one nucleotide substitution at a position from nucleotide 12 to 16 of SEQ D No. 1, wherein the nucleotide positions of SEQ ID No. 1 are numbered from the 3'- to the 5'-end; as well as to an expression cassette, vector and pharmaceutical composition comprising at least one isolated miR-206 target site of the invention.
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申请公布号 |
US2013281508(A1) |
申请公布日期 |
2013.10.24 |
申请号 |
US201213450392 |
申请日期 |
2012.04.18 |
申请人 |
FECHNER HENRY;ANJA GEISLER;CHARITE-UNIVERSITATSMEDIZIN BERLIN;TECHNISCHE UNIVERSITAT BERLIN |
发明人 |
FECHNER HENRY;ANJA GEISLER |
分类号 |
A61K31/7088;A61P9/00;A61P9/12;C12N15/113;C12N15/63 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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