| 发明名称 |
MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO |
| 摘要 |
<p>The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (1), in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.</p> |
| 申请公布号 |
EP1807074(B1) |
申请公布日期 |
2013.10.23 |
| 申请号 |
EP20050818207 |
申请日期 |
2005.11.03 |
| 申请人 |
CURIS, INC.;GENENTECH, INC. |
发明人 |
GUICHERIT, OIVIN M.;BOYD, EDWARD ANDREW;BRUNTON, SHIRLEY ANN;PRICE, STEPHEN;STIBBARD, JOHN HARRY ALEXANDER;MACKINNON, COLIN H. |
| 分类号 |
A61K31/4184;A61P35/00;C07D401/10;C07D401/14;C07D413/10;C07D417/10;C07D417/14 |
主分类号 |
A61K31/4184 |
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