发明名称 TRICYCLIC NUCLEIC ACID ANALOGS
摘要 The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.
申请公布号 WO2013154798(A1) 申请公布日期 2013.10.17
申请号 WO2013US33149 申请日期 2013.03.20
申请人 ISIS PHARMACEUTICALS, INC. 发明人 SETH, PUNIT, P.;SWAYZE, ERIC, E.;HANESSIAN, STEPHEN;SCHROEDER, BENJAMIN, R.;GIACOMETTI, ROBERT, D.;MERNER, BRADLEY, L.
分类号 C07H19/06;C07H21/00 主分类号 C07H19/06
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