Genetically stable attenuated polioviruses comprising multiple mutations in domain V of the 5' noncoding region

摘要

The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5' non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.