摘要 |
PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent for obesity, having excellent drug efficacy even in a usual administration form such as peripheral administration.SOLUTION: There is provided: a peptide derivative selected from the group consisting of PEG20k(AL)-&bgr;-Ala-Tyr-Nal(1)-Leu-Phe-Arg-Pro-Arg-Asn-NH, PEG20k(AL)-&bgr;-Ala-Tyr-Nal(2)-Leu-Phe-Arg-Pro-Arg-Asn-NH, PEG20k(AL)-NpipAc-Tyr-Nal(2)-Leu-Phe-Arg-Pro-Arg-Asn-NH, PEG20k(AL)-NpipAc-Tyr-Nal(2)-Leu-Phe-Arg-Ala-Arg-Asn-NH, PEG20k(AL)-PEG(2)-Tyr-Nal(2)-Leu-Phe-Arg-NMeAla-Arg-Asn-NHand the like; or its salt. |