| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method for preparing 1,2-dihydronaphtho[2,1-b]furanes containing 1-adamantanoyl group in the second position, by reaction of substituted 1-[(dimethylamino)methyl]-2-naphtholes with 1-[2-(1-adamantyl)-2-oxoethyl]pyridinium bromide in molar ratio 1:1 in the ethanol medium at 78°C in the presence of 1,1,3,3-tetramethylguanidine or 1,8-diazabicyclo[5.4.0]undec-7-ene. These compounds are advanced parent compound for the purpose of the synthesis of pharmacologically active substances.EFFECT: provided reaction selectivity, simplified process procedure and cost reduction of the production process ensured by using the available naphthalene Mannich bases and storage-stable 1-[2-(1-adamantyl)-2-oxoethyl]pyridinium bromide.1 cl, 8 ex |
