发明名称 |
FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS |
摘要 |
The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of &bgr;ig-h3 lacking H1 and H2 regions; b) a MMP (Matrix metalloproteinase) substrate; and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells. |
申请公布号 |
EP2646473(A2) |
申请公布日期 |
2013.10.09 |
申请号 |
EP20110845862 |
申请日期 |
2011.12.02 |
申请人 |
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY- ACADEMIC COOPERATION FOUNDATION |
发明人 |
KANG, YOUNG MO;KIM, IN SAN;KANG, JIN HEE;SA, KEUM HEE |
分类号 |
C07K19/00;A61K38/17;A61P19/02;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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