SYSTEM FOR IDENTIFYING CONNECTIONS BETWEEN PERTURBAGENS AND GENES ASSOCIATED WITH A SKIN HYPERPIGMENTATION CONDITION

摘要

A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition using Connectivity map. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent. The system also includes a programmable computer with computer- readable instructions that allow the computer to accessing the instances and a hyperpigmentation-relevant gene expression signature stored on the computer readable medium, comparing the hyperpigmentation- relevant gene expression signature to the plurality of the instances, and/or assigning a connectivity score to each of the plurality of instances.