发明名称 |
ANTIBODIES TO BRADYKININ B1 RECEPTOR LIGANDS |
摘要 |
The disclosure provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The disclosure also provides pharmaceutical compositions, as well as nucleic acids encoding anti-Kallidin or des- Arg10-Kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the disclosure to modulate Kallidin or des-Arg10- Kallidin activity or detect Kallidin or des-Arg10-Kallidin or, either in vitro or in vivo, are also provided by the disclosure. The disclosure further provides methods of making antibodies that specifically bind to des-Argg- Bradykinin and des-Arg10-Kallidin-like peptide. |
申请公布号 |
WO2013148296(A1) |
申请公布日期 |
2013.10.03 |
申请号 |
WO2013US31836 |
申请日期 |
2013.03.15 |
申请人 |
SANOFI;LI, HAN |
发明人 |
LI, HAN;KOMINOS, DOROTHEA;ZHANG, JIE;PRITSKER, ALLA;DAVISON, MATTHEW;BAURIN, NICOLAS;SUBRAMANIAN, GOVINDAN;CHEN, XIN |
分类号 |
C07K16/26;A61K39/395;A61P29/00;C07K7/18 |
主分类号 |
C07K16/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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