METHOD OF TREATING PULMONARY FIBROSIS

摘要

FIELD: medicine.SUBSTANCE: hyaluronidase immobilised on polyethylene glycol is introduced into laboratory animals intranasally in a dose of 16 units. Hyaluronidase is introduced once a day on 1, 3, 7and 10day after administering bleomycin that is a pulmonary fibrosis simulation factor.EFFECT: higher pulmonary tissue resistance to fibrotic depositions, including prevents a reverse process of fibrosis formation ensured by the properties of pegylated hyaluronidase and developed mode of its administration that leads to a prolonged antifibrotic effect with low toxicity and immunogenicity of the effects on the body.1 ex, 1 tbl