发明名称 |
Controlled agglomeration |
摘要 |
A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier, which has a melting point of about 5° C. or more which is present in the first composition in liquid form, on a second composition comprising a material in solid form, the second composition having a temperature of at the most a temperature corresponding to the melting point of the carrier and/or the carrier composition and ii) mixing or others means of mechanical working the second composition onto which the first composition is sprayed to obtain the particulate material.
|
申请公布号 |
US8535799(B2) |
申请公布日期 |
2013.09.17 |
申请号 |
US20070711965 |
申请日期 |
2007.02.27 |
申请人 |
BURR ANDERS;RINGKJOEBING-ELEMA MICHIEL;HOLM JANNIE EGESKOV;HOLM PER;MOELLGAARD BIRGITTE;SCHULTZ KIRSTEN;VELOXIS PHARMACEUTICALS A/S |
发明人 |
BURR ANDERS;RINGKJOEBING-ELEMA MICHIEL;HOLM JANNIE EGESKOV;HOLM PER;MOELLGAARD BIRGITTE;SCHULTZ KIRSTEN |
分类号 |
A61K9/14;A61K47/02;A61K9/10;A61K9/16;A61K9/20;A61K9/48;A61K47/10;A61K47/12;A61K47/14;A61K47/26;A61K47/32;A61K47/34;A61K47/44;B01J2/00;B01J2/02 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|