Transformed strains originated from multidrug efflux protein defective strains and a method for microbial conversion using them

摘要

Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion using a transformant having a gene derived from a heterogeneous organism integrated therein. A microorganism having the deletion of a gene encoding a multidrug efflux protein is used as a host to produce a transformant having a gene derived from a heterogeneous organism integrated therein. By using the transformant in bioconversion, it becomes possible to convert a hydrophobic or amphipathic substrate compound into a desired compound with extremely high efficiency. When an