PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF

摘要

PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF AbstractThe present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E, activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.Figure I