发明名称 |
PARKINSON'S DISEASE MODEL MICE, PREPARATION METHOD THEREOF, AND SCREENING METHOD FOR PARKINSON'S DISEASE USING THEM |
摘要 |
PURPOSE: A Parkinson's disease model mouse, a preparation method thereof, and a screening method for Parkinson's disease using the same are provided to be utilized for pathological mechanism researches. CONSTITUTION: A Parkinson's disease model mouse lacks a CR6-interacting factor 1 gene in the dopamine type neuron cells. A preparation method of the Parkinson's disease model mouse comprises the following steps: obtaining a CRIF1 heterozygous knockout first generation mouse having CRIF1 loxp/+ and DAT-Cre m/+ genotypes by crossing a CRIF1 loxp/loxp mouse and a DAT-Cre mouse; obtaining a second generation mouse by crossing the heterozygous knockout mouse and a CRIF1 loxp/loxp mouse; and selecting a CRIF1 homozygous knockout mouse having CRIF1 loxp/loxp and DAT-Cre m/+ genotypes from the second generation mouse. |
申请公布号 |
KR101301486(B1) |
申请公布日期 |
2013.08.29 |
申请号 |
KR20120043311 |
申请日期 |
2012.04.25 |
申请人 |
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) |
发明人 |
SHONG, MIN HO;KWEON, GI RYANG;HEO, JUN YOUNG;KIM, SOUNG JUNG |
分类号 |
A01K67/027;C12N5/071;G01N33/15 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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