| 摘要 |
Systems and methods for modeling a compound formulation are provided. In one implementation, a method consistent with the disclosure comprises receiving compound parameters including an excipient parameter identifying an excipient combination to be used in developing the compound formulation and a water concentration parameter identifying a water concentration to be used in diluting the excipient combination; storing, in a database, formulation data associated with a plurality of excipient combinations and solubility data associated with a plurality of pharmaceutical ingredients dissolved in the respective excipient combinations; transforming the formulation data and the solubility data into a formulation model space, where points in the formulation model space reflect compositions of the identified excipient combination; and generating a compound formulation model based on the formulation model space, where the compound formulation model graphically identifies one or more compositions of the identified excipient combination that satisfy the compound parameters. |
