| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to medicine, pharmaceutics and nanotechnologies, and more specifically to a method for preparing nanosized amphotericin B for coating aluminosilicate nanotubes, used as a poorly soluble polyene macrocyclic antibiotic widely used for treating fungal diseases. What is presented is the method for preparing nanosized amphotericin B by mixing a solution of amphotericin B in dimethyl sulphoxide at room temperature with the aluminosilicate tubes to make 1-20 wt % of amphotericine B precipitate on the aluminosilicate tubes by water treatment of the prepared mixture while stirring thoroughly at water feed rate 10 ml/min. The technical effect consists in the fact that the presented method is simple and easy to implement, and enables producing a novel dosage form of amphotericin B represented by amphotericin B coating the solid inorganic structures that are the aluminosilicate tubes; the above shall provide the further development of new ointments, gels and magmas for treating fungal diseases.EFFECT: using the nanosized carrier promotes the uniform distribution of amphotericin B, while an aluminosilicate nature of the carrier is a good sorbent that provides prolonged action of amphotericin B with the carrier staying undisturbed that also allows for higher bioavailability of insoluble amphotericin B as compared to microforms thereof.1 cl, 4 ex |
