摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method of treating cancer in a patient, wherein the method involves administering a cancer-inhibiting amount of a compound of formula I into a patient's body. The method of treating cancer in the patient, including a human, wherein the method involves administering the cancer-inhibiting amount of a first compound of formula Ior a physiologically acceptable salt thereof into the patient's body, wherein X represents CH or N, each Rindependently represents hydrogen or -CHCOR; Rrepresents hydroxy, optionally hydroxylated alkoxy, amino or alkylamino; each Rindependently represents the group ZYR; Z represents a bond or the Calkylene or oxoalkylene group optionally substituted by the group R; Y represents a bond, an oxygen atom or the group NR; Ris a hydrogen atom, the group COOR, the alkyl, alkenyl, cycloalkyl, aryl or aralalkyl group optionally substituted by one or more groups COOR, CONR?, NR?, OR, =NR, =O, OP(O)(OR)Rand OSOM; Ris hydroxy, the optionally alkoxylated or aminoalkyl group; Ris a hydrogen atom or the optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically acceptable cation; Rrepresents the Calkylene group, 1,2-cycloalkylene group or 1,2-arylene group, optionally substituted by R; and each Rindependently represents hydrogen or Calkyl.EFFECT: invention refers to a pharmaceutical composition for treating cancer in the patient, containing the compound of formula I, as well as to a kit for treating cancer.23 cl, 3 ex, 7 dwg |