发明名称 |
Monoclonal anti-claudin 1 antibodies for the inhibition of hepatitis C virus infection |
摘要 |
The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described.
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申请公布号 |
US8518408(B2) |
申请公布日期 |
2013.08.27 |
申请号 |
US200913119233 |
申请日期 |
2009.09.25 |
申请人 |
BAUMERT THOMAS;SCHUSTER CATHERINE;THOMPSON JOHN;GRUNERT FRITZ;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITY DE STRASBOURG |
发明人 |
BAUMERT THOMAS;SCHUSTER CATHERINE;THOMPSON JOHN;GRUNERT FRITZ |
分类号 |
A61K39/42;C12N5/12;C12P21/08 |
主分类号 |
A61K39/42 |
代理机构 |
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