发明名称 |
Methods and Therapeutics Comprising Ligand-Targeted ELPs |
摘要 |
Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (ELP) component and a ligand selected from the group consisting of mIgA and knob capable of either drug encapsulation or drug attachment. Further aspects relate to drug delivery systems comprising an elastin-like peptide (ELP) component and a ligand; wherein the ligand specifically binds to a receptor selected from the group consisting of CAR and pIgR. Further aspects include the novel transcytosing properties of the elastin-like peptide and the ligand, knob. Also provided are methods and pharmaceutical compositions comprising the disclosed therapeutics.
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申请公布号 |
US2013210747(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201313764476 |
申请日期 |
2013.02.11 |
申请人 |
UNIVERSITY OF SOUTHEM CALIFORNIA;UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
HAMM-ALVAREZ SARAH;MACKAY JOHN ANDREW;SUN GUOYONG;HSUEH PANG-YU |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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