发明名称 |
PROCESS FOR PRODUCING SPHERICAL ELEMENTARY GRANULE CONTAINING READILY WATER-SOLUBLE DRUG |
摘要 |
Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass% or greater and a water absorbing capacity of 0.5 cm 3 /g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide. |
申请公布号 |
EP2042162(A4) |
申请公布日期 |
2013.08.14 |
申请号 |
EP20070790954 |
申请日期 |
2007.07.18 |
申请人 |
ASAHI KASEI CHEMICALS CORPORATION |
发明人 |
YAGINUMA, YOSHIHITO;MATSUMOTO, RIKA |
分类号 |
A61K9/16;A61K31/192;A61K31/4402 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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