摘要 |
A method for carrying out an NMR experiment with enhanced sensitivity on a compound comprising hyperpolarizable nuclei, with the steps of : a) preparing1 a fluid containing spacially symmetric molecules comprising two halves each, with a non-Boltzmann nuclear spin state distribution of the symmetric molecules, b) providing a compound with a defined chemical identity, c) providing a template that offers sites of ordered environment for the two halves of a symmetric molecule and a compound which can be arranged at each site, d) bringing together the prepared fluid, the compound and the provided template, thereby transferring the spin order from the symmetric molecules to the hyperpolarizable nuclei of the compound during a temporary association of the symmetric molecules, the compound, and the template while ultimately keeping the chemical identity of the compound, and e) performing an NMR measurement on the compound comprising hyperpolarized nuclei prepared in step d).
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