| 摘要 |
FIELD: biotechnologies.SUBSTANCE: methods are described for synthesis of intermediate compounds used in synthesis of analogues of halichondrin B, in particular, the method to produce substantially diastereomer-pure composition of the compound with the formulaincluding: crystallisation of the specified compound of the formula (I) from the mixture of diastereomers with production of a composition, in which the ratio of the specified compound of the formula (1) to a compound with the opposite stereochemical configuration of chiral centre, indicated with an asterick, makes at least 8:1, where the specified compound of the formula (I) represents: where: z is a single or double link, provided that whenever z is a double link, Xis C, and Yis a hydrogen atom; and provided that when z is a single link, X is CH or O; Xis O; Yis a halogen atom, a hydrogen atom or O-L, or is absent, when X is O; Land Lindependently represent a hydrogen atom or a protective group, or Land Ltogether are a protective group; or its salt. The invention also includes a whole row of intermediate compounds and a composition of a mixture of separate diastereomers of these compounds.EFFECT: improved properties of compounds.75 cl, 15 ex |
