<p>The invention relates to recombinantly producedβ-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variantβ-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a targetβ-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.</p>
申请公布号
EP2443235(A4)
申请公布日期
2013.07.31
申请号
EP20100790160
申请日期
2010.06.16
申请人
CODEXIS, INC.
发明人
ZHANG, XIYUN;YANG, JIE;BAIDYAROY, DIPNATH;POSTLETHWAITE, SALLY RHIANNON;ANDOR, ATTILA;CLARK, LOUIS;NEWMAN, LISA, M.