| 摘要 |
<p>The invention encompasses in one aspect a method for obtaining a thrombin binding agent which inhibits thrombin activity but causes minimal or no inhibition of haemostasis and/or causes minimal or no bleeding, the method comprising the step of screening a candidate binding agent for the present or absence of an exosite 1 binding agent which has an exosite 1 binding motif consensus amino acid sequence as defined herein. The invention also encompasses thrombin binding agents suitable for use as anticoagulants which cause minimal or no bleeding, thrombin binding agents per se, and related methods and uses.</p> |
