摘要 |
The present invention relates to a process for the enzymatic synthesis of the compound of formula (I):wherein R1 represents a hydrogen atom or a C1-C6 alkyl group, preferably methyl, and also to its application in the synthesis of ivabradine of formula (II):or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, its addition salts with a pharmaceutically acceptable acid and their hydrates.The use of hydrolytic enzymes (hydrolases), which function without cofactors, such as lipases or esterases, makes it possible to obtain chiral compounds - key intermediates in the synthesis of pharmaceutical active ingredients - in high enantiomeric excesses and good yields. |