发明名称 |
TREATMENT OF ALZHEIMER'S DISEASE BY TARGETING MIRNA |
摘要 |
<p>The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.</p> |
申请公布号 |
EP2617433(A2) |
申请公布日期 |
2013.07.24 |
申请号 |
EP20110825393 |
申请日期 |
2011.09.09 |
申请人 |
SNU R&DB FOUNDATION |
发明人 |
ROH, JAE-KYU;LEE, SANG KUN;KIM, MAN HO;CHU, KON;JUNG, KEUN-HWA;LEE, SOON-TAE |
分类号 |
A61K31/7105;A61K31/7088;A61K31/711;A61P25/28 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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