发明名称 |
METHOD FOR CONSTRUCTING LIBRARIES OF NON-STANDARD PEPTIDE COMPOUNDS COMPRISING N-METHYL AMINO ACIDS AND OTHER SPECIAL (NON-STANDARD) AMINO ACIDS AND METHOD FOR SEARCHING AND IDENTIFYING ACTIVE SPECIES |
摘要 |
A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free ( in vitro ) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide. |
申请公布号 |
EP2615455(A1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20110823628 |
申请日期 |
2011.09.08 |
申请人 |
THE UNIVERSITY OF TOKYO |
发明人 |
SUGA, HIROAKI;YAMAGISHI, YUSUKE |
分类号 |
C12N15/10;C07K7/08;C12N15/67;C12P21/02;C40B40/08;C40B40/10;G01N33/50 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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