发明名称 |
METHOD FOR THE TREATMENT OF RETINOPATHY OF PREMATURITY AND RELATED RETINOPATHIC DISEASES |
摘要 |
<p>The present invention provides the use of cells from a vasculotrophic lineage negative hematopoietic stem cell population for the preparation of a pharmaceutical composition for treating a mammal suffering from or at risk of developing retinopathy of prematurity or a related retinopathic disease wherein the cells are transfected with a therapeutically useful gene encoding for an angiostatic fragment of Trp-RS and wherein the pharmaceutical composition is for administering to the retina of the mammal an amount of cells from a vasculotrophic lineage negative hematopoietic stem cell population effective to promote beneficial physiological revascularization of damaged areas of the retina and to ameliorate damage to the retina caused by the disease.</p> |
申请公布号 |
EP1853244(B1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20060736134 |
申请日期 |
2006.02.24 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
FRIEDLANDER, MARTIN;BANIN, EYAL;AGUILAR, EDITH |
分类号 |
A61K31/137;A01N63/00;A01N65/00;A61K48/00;C12N5/0789;C12N15/00 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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