发明名称 |
NOVEL MAYTANSINOID DERIVATIVES WITH PEPTIDE LINKER AND CONJUGATES THEREOF |
摘要 |
The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. |
申请公布号 |
WO2012177837(A3) |
申请公布日期 |
2013.07.11 |
申请号 |
WO2012US43488 |
申请日期 |
2012.06.21 |
申请人 |
IMMUNOGEN, INC.;WIDDISON, WAYNE, C. |
发明人 |
WIDDISON, WAYNE, C. |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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