AMINOPYRIMIDINE-BASED DERIVATIVES HAVING PI3Kβ INHIBITING ACTIVITY, PI3Kβ INHIBITING COMPOSITION COMPRISING THE DERIVATIVES AND METHOD FOR PREPARING THE SAME

摘要

PURPOSE: An aminopyrimidine-based derivative which suppresses PI3K beta and a PI3K beta inhibitor composition containing the same are provided to ensure excellent activity to PI3K beta with high selectivity and to treat diseases related to PI3K beta. CONSTITUTION: An aminopyrimidine-based derivative or a pharmaceutically acceptable salt thereof is denoted by chemical formula 3. The pharmaceutically acceptable salt is non-toxic acid addition salts, basic addition salts, metal salts, amino acid salts, or organic salts containing pharmaceutically acceptable anions. A PI3K beta inhibitor composition contains the aminopyrimidine-based derivative of chemical formula 3 as an active ingredient, and pharmaceutically acceptable carriers or diluents. A method for preparing the aminopyrimidine-based derivative comprises the step of preparing a compound of chemical formula 3 through Suzuki coupling reaction of compounds of chemical formulas 5 and 6. A method for preparing the aminopyrimidine-based derivative comprises the step of treating a compound of chemical formula 8 with R1C1.