| 摘要 |
A compound of formula (1)
including pharmaceutically acceptable salts thereof, wherein:
R 1 is aryl or heteroaryl optionally substituted with R 8 ;
R 2 is H or alkyl or CH 2 (when forming part of a ring with R 3 , R 4 or R 5 );
R 3 is H, alkyl, CH 2 OH or CH 2 OR 6 and can be part of a ring with R 2 ;
R 4 is H, alkyl, CH 2 OH or CH 2 OR 6 and can be part of a ring with R 2 ;
R 5 is H, alkyl, CH 2 OH or CH 2 OR 6 and can be part of a ring with R 2 ;
R 6 is alkyl, COH, COOR 9 , CON(R 9 ) 2 , COR 9 , COR 10 , COR 11 , P(O) n R 9 , P(O) n R 10 S(O) n R 10 or S(O) n R 9 and can be part of a ring with R 2 , R 3 , R 4 or R 5 ;
R 7 is H, alkyl, COOR 9 , COOR 11 , COR 9 or CON(R 9 ) 2, and can be part of a ring with R 2 , R 3 , R 4 , R 5 or R 6 ;
R 8 is alkyl, CF 3 , OR 9 , OCOR 9 , CONH 2 , CN, F, Cl, Br, I, N(R 9 ) 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 R 9 , CON(R 9 ) 2 , S(O) n R 9 , CH 2 OH or OCON(R 9 ) 2 ;
R 9 is H, alkyl or cycloalkyl;
R 10 is aryl or heteroaryl optionally substituted with R 8 or a four to seven membered ring optionally substituted with R 8 and containing one or more additional heteroatoms selected from O, S(O) n and NR 9 ;
R 11 is alkyl optionally substituted with R 8 or R 10 ; and
n is 0, 1 or 2;
provided that when R 3 , R 4 or R 5 is CH 2 OH then R 6 is not H, and that when R 7 is H and R 3 , R 4 and R 5 are alkyl then R 6 is not H. |
