| 摘要 |
A compound having the formula (see above formula) , wherein Z is a member selected from O, S, C(R2)2 and NR2; X is a member selected from H, ¨OR3, ¨ NR3R4, ¨SR3, and -CHR3R4; R2, R3 and R4 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstitutedheteroaryl, substituted or unsubstituted heterocycloalkyl, -C(=M)R5, -C(=M)-Z-R5, -SO2R5, and -SO3; wherein M and Z are members independently selected from O, NR6 and S; Y is a member selected from H, -OR7, -SR7, -NR7R8, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocycloalkyl; wherein R5, R6, R7 and R8 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl; R11 and R12 are members independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted hetero cyclo alkyl, NR14R15, OR14, -CN and ¨C(=L)R14; wherein L is a member selected from O, S, and NR16; R13 is selected from substituted or unsubstituted heterocycloalkyl, OR17 and NR17R18; and R14 and R15 is selected from H, substituted or unsubstituted alkyl, substituted or nsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, C(O)R17, OR17 and NR17¨ 18; wherein R16, R17 and R18 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl.
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