发明名称 |
Avian influenza virus live attenuated vaccine and uses thereof |
摘要 |
Described in this application are attenuated strains of avian influenza virus containing temperature sensitive mutations in addition to a genetic tag in the PB1 gene. The attenuated viruses are useful as avian and mammalian vaccine for protective immunity against homologous and heterologous lethal challenges with influenza virus. A genetically modified avian influenza virus backbone is described which can be used as a master donor strain for the generation of live attenuated vaccines for epidemic and pandemic influenza.
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申请公布号 |
US8475807(B2) |
申请公布日期 |
2013.07.02 |
申请号 |
US20090381550 |
申请日期 |
2009.03.13 |
申请人 |
PEREZ DANIEL R.;UNIVERSITY OF MARYLAND COLLEGE PARK |
发明人 |
PEREZ DANIEL R. |
分类号 |
C12Q1/70;C12N15/00 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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