595891 MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI Provided is the use of a Factor XI modulator compound in the manufacture of a medicament for modulating an inflammatory response in an animal. The modulator can be a modified oligonucleotide targeting Factor XI, a peptide, antibody or small molecule. Specific antisense oligos suitable for the purpose are also disclosed.
申请公布号
NZ595891(A)
申请公布日期
2013.06.28
申请号
NZ20100595891
申请日期
2010.04.15
申请人
ISIS PHARMACEUTICALS, INC.
发明人
MONIA, BRETT, P;CROSBY, JEFFREY, R;MACLEOD, ROBERT, A;FREIER, SUSAN, M