| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide alternative compositions and methods for increasing red blood cell levels in patients. <P>SOLUTION: The disclosure provides methods for using activin-ActRII antagonists (including, for example, activin-binding ActRIIa polypeptides, activin-binding ActRIIb polypeptides, anti-activin antibodies, anti-ActRIIa antibodies, anti-ActRIIb antibodies, activin-, ActRIIb-, or ActRIIa-targeted small molecules and aptamers, and nucleic acids that decrease expression of activin, ActRIIb, or ActRIIa) to increase red blood cell and hemoglobin levels in patients and to treat disorders associated with low red blood cell or hemoglobin levels in patients in need thereof. <P>COPYRIGHT: (C)2013,JPO&INPIT |
