发明名称 |
THREE-DIMENSIONAL CAVITIES OF DENDRITIC CELL IMMUNORECEPTOR (DCIR), COMPOUNDS BINDING THERETO AND THERAPEUTIC APPLICATIONS RELATED TO INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) |
摘要 |
The invention is concerned with compounds, pharmaceutical compositions, screening methods, and therapeutic methods for preventing or reducing a human immunodeficiency virus type-1 (HIV-1) infection and/or propagation associated with dendritic cell immunoreceptor (DCIR). Described herein are compounds which bind on at least one three-dimensional cavity of the DCIR, the cavity(ies) being involved in the interaction between HIV-1 and DCIR. Also described are screening methods for identifying active inhibitors and method of using such inhibitors for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus type-1 (HIV-1) binding, entry and/or replication in human cells. |
申请公布号 |
WO2013091089(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
WO2012CA01196 |
申请日期 |
2012.12.20 |
申请人 |
UNIVERSITE LAVAL |
发明人 |
GILBERT, CAROLINE;TREMBLAY, MICHEL J.;LIN, SHENG-XIANG;AZZI, AREZKI;LAMBERT, ALEXANDRA |
分类号 |
A61K31/655;A61K31/12;A61K31/343;A61K31/352;A61K31/404;A61K31/41;A61K31/4245;A61K31/427;A61K31/428;A61K31/4439;A61K31/47;A61K31/501;A61P31/18;C07K14/705;C12Q1/70;C40B30/02;G06F19/16 |
主分类号 |
A61K31/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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