发明名称 |
ORALLY DISINTEGRATING TABLET AND PROCESS FOR PREPARING THE SAME |
摘要 |
PURPOSE: An orally disintegrating tablet is provided to enable stable sustained release, to improve hardness, and to ensure convenient process, storage, and drug administration. CONSTITUTION: An orally disintegrating tablet contains a particle and a disintegrating agent. A method for manufacturing the orally disintegrating tablet comprises: a step of coating an inactive core with a drug layer containing tamsulosin or a pharmaceutically acceptable salt thereof; a step of coating the drug layer with a first coating layer containing a first sustained release polymer and a water soluble polymer; a step of coating the first coating layer with a second layer containing a second sustained release polymer and plasticizer with a pour point less than -10 deg. C; and a step of mixing the formed particle and tableting. [Reference numerals] (AA) Tamsulosin elution rate according to hardness at pH 1.2; (BB) Elution rate(%); (CC) Comparative example 1; (DD) Example 1; (EE) Example 2; (FF) Example 3; (GG) Example 4
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申请公布号 |
KR20130067695(A) |
申请公布日期 |
2013.06.25 |
申请号 |
KR20110134514 |
申请日期 |
2011.12.14 |
申请人 |
BIO PHARMARTIS CO., LTD. |
发明人 |
LEE, SANG JOON;CHANG, KWAN YOUNG;AHN, JAE SOON;CHO, JAE MIN;KANG, KYOUNG UN;CHAE, JI MAN;NA, SEONG JU;NAM, DAE SIK;LEE, HYUN JOO;PARK, YOUNG JOO |
分类号 |
A61K9/22;A61K9/20;A61K47/30;A61K47/38 |
主分类号 |
A61K9/22 |
代理机构 |
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