| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to N-hydroxylsulphonamide derivatives of formulaor, where Ris H; Ris H; n is 0; b is an integer in the range of 1-4; R, R, R, Rand Rare independently selected from H, halogen, carboxyl, carboxyl ester selected from a group including -C(O)O-morpholino, -C(O)O-C-Calkyl and -C(O)O-substituted C-Calkyl, where the substitute is morpholino; acylamino, which is a -C(O)NRRgroup, where Rand Rare independently C-Calkyl, or Rand Rtogether with a nitrogen atom to which they are bonded form morpholino; and sulphonylamino, which is a SONRgroup, where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; Ris selected from halogen and carbonylamino, selected from a -CONH-substituted C-Calkyl, where the substitute is morpholino; and -CONR, where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; C is a heteroaromatic ring which contains cyclic fragments Q, Q, Q, Q, Qand Q, which are independently selected from C, CH and S, under the condition that at least one of the fragments Q, Q, Q, Q, Qand Qis S. The invention also relates to a method of modulating nitroxyl levels, a method of treating diseases which respond to treatment with nitroxyl, a treatment set and a pharmaceutical composition containing compounds of formula (I) or (III).EFFECT: compounds of formula (I) or (III) for treating diseases which respond to treatment with nitroxyl.20 cl, 5 ex, 4 tbl, 7 ex |
